Ancient Sanskrit texts like the Mahabharata, the Ramayana, as well as Puranas describe the nagas as a robust, splendid and happy semi-divine species that could presume their physical sort either as human (often which has a halo of cobra hoods guiding their head), to be a partly human serpent, or in general serpent. Their area is inside the enchanted underworld, the underground realm crammed with gems, gold as well as other earthly treasures termed Naga-loka or Patala-loka. They are also normally connected with bodies of waters — including rivers, lakes, seas, and wells — and are guardians of treasure.[ten] Their energy and venom make them possibly perilous to humans. On the other hand, in Hindu mythology, they generally go ahead and take role of benevolent protagonists; from the Samudra Manthana, Vasuki, a nagaraja who abides on Shiva's neck, became the churning rope for churning in the Ocean of Milk.

s are Shesha (or Ananta), who in the Hindu fantasy of development supports Narayana (Vishnu) as he lies over the cosmic ocean and on whom the developed planet rests; Vasuki, who was made use of as being a churning rope to churn the cosmic ocean of milk; and Takshaka, the tribal chief on the snakes.

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Mutation of Y223 to the phenylalanine residue resulted in a mutant with almost precisely the same catalytic activity since the wild kind enzyme and therefore this residue just isn't considerable for your binding of substrate in NagA.

m noticed for the different metals Keep to the development: Zn = Co > Mn > Cd > Fe > Ni . The Fe containing enzyme wasn't absolutely reconstituted with metallic and therefore the kinetic constants may very well be much larger In case the metallic internet site was completely occupied. The values for k

For login naga26 The one histidine substitutions, the N61H mutant is comparable in catalytic activity into the double mutant While the Q59H mutant is diminished by under an buy of magnitude relative for the wild variety enzyme. With the substitutions at Asn-sixty one, the substitute with an alanine is considerably fewer disruptive as opposed to modify into a histidine.

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a could be the acid dissociation continual. pH-amount profiles that confirmed the lack of catalytic activity at higher and very low values of pH had been fit to link naga26 equation 4, the place K

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m profile (Table three). These final results are absolutely in keeping with the summary that the next ionization observed from the pH-level profile for log k

m values were being determined from matches of the data to some straight line. Saturation curves showing substrate inhibition were being match to equation 2 were being K

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